Endocrine Abstracts

Fibroblast growth factor-23 (FGF23) FGF23 is a bone-derived hormone which down-regulates renal proximal tubular phosphate reuptake and 1α-hydroxylase expression, the key enzyme for production of the vitamin D hormone, 1α, 25-dihydroxyvitamin D3 (1.25(OH)2D). The molecular mechanism of the phosphaturic action of FGF23 has recently been elucidated. FGF23 directly downregulates membrane expression of the sodium-phosphate cotransporter NaPi-2a in pr...